Henoch- Schonlein Purpura

Most common vasculitis in children ?

Acute Kidney injury + abdominal pain + palpable purpura = ?

Child with sore throat, runny nose, cough   → 1 week later → muscle aches , red purple rash over arms, buttocks and legs →one month later → fatigue and hematuria  = ?

Answer

Henoch–Schönlein purpura (HSP)

 HSP  represents with

 palpable purpura,

 diffuse abdominal pain, 

arthritis,

 arthralgia,

 hematuria, 

and/or proteinuria.

HSP can also represent as glomerulonephritis.

HSP glomerulonephritis is characterized by immunoglobulin A (IgA) deposition

 HSP usually precedes an infection, such as a throat infection.

HSP is a systemic vasculitis (inflammation of blood vessels) and is characterized by deposition of immune complexes containing the antibody immunoglobulin A (IgA).

Treatment

symptom control

resolves on its own

Important Medicine points

1.Anisocytosis - Variation in the size of RBCs





2.Thalassemia -- target cells

3.Ferritin is acute phase reactant

4.Patient's with mechanical mitral valve have double the risk of stroke compared to those with mechanical aortic valve.

5.Rotator cuff tendinitis - lateral shoulder pain and this is increased by abduction and external rotation

6.If standardised error of measurement bars overlap there is no significant statistical difference

7.Acute bronchitis can present with rhonchi and wheezing but not CRACKLES as they represent disease beyond bronchioles

8.Sarcoidosis forms non caseating granulomas in lymph nodes, lungs and other organs

9.Sarcoid granuloma---- hypercalcemia

Sarcoid granuloma has activated macrophage which secrete 1 alpha hydroxylase

1,25 hydroxy vit d → 1,25 dihydroxy vit d →increases GI calcium absorption